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Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage
Chu and Hellmuth et al.
Mol Cell. 2020. PubMed PMID: 33232656.
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Our results demonstrate how an intimately linked complex of lineage- and stage-specific factors converges on specific and highly essential enhancer elements to drive the function of a cell-type defining LCR.
Duodenal-type and nodal follicular lymphomas differ by their immune microenvironment rather than their mutation profiles
Hellmuth and Louissaint et al.
Blood. 2018. PubMed PMID: 30126979.

Duodenal-type follicular lymphoma (DTFL) is a rare and highly indolent follicular lymphoma (FL) variant. Comparative molecular characterization of DTFL to typical FL revealed distinct pathogenic mechanisms.

Abstract Highlights

Hellmuth JC*, Chu CS*, Singh R, Skrabanek LA, Doane A, Elemento O, Roeder RG, Melnick A.
An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells.
Blood. 2019 Nov 13;134(Supplement_1):24. doi: 10.1182/blood-2019-130692.